Effect of xylitol varnishes on remineralization of artificial enamel caries lesions in situ

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• 作者：C.A.B. Cardoso^a ; L.P.S. Cassiano^b ; E.N. Costa^b ; C.M. Souza-e-Silva^b ; A.C. Magalhã ; es^b ; L.T. Grizzo^b ; M.L. Caldana^c ; J.R.M. Bastos^c ; M.A.R. Buzalaf^b ; ^{mbuzalaf@fob.usp.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dental caries ; Dental remineralization ; Fluoride varnish ; Xylitol
• 刊名：Journal of Dentistry
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：50
• 期：Complete
• 页码：74-78
• 全文大小：491 K

文摘

Analyze the effect of varnishes containing xylitol compared to commercial fluoridated varnishes on the remineralization of artificial enamel caries lesions in situ.

Methods

Twenty subjects took part in this crossover, double-blind study performed in four phases of 5 days each. Each subject worn palatal appliances containing four predemineralized bovine enamel specimens. Artificial caries lesions were produced by immersion in 30 ml of lactic acid buffer containing 3 mM CaCl₂·2H₂O, 3 mM KH₂PO₄, 6 μM tetraetil metil diphosphanate (pH 5.0) for 6 days. The specimens in each subject were treated once with the following varnishes: 20% xylitol (experimental); Duofluorid™ (6% NaF, 6% CaF₂), Duraphat™ (5% NaF, positive control) and placebo (no-F/xylitol, negative control). The varnishes were applied in a thin layer and removed after 6 h. Fifteen subjects were able to finish all phases. The enamel alterations were quantified by surface hardness and transversal microradiography. The percentage of surface hardness recovery (%SHR), the integrated mineral loss and lesion depth were statistically analyzed by Friedmann and Dunn’s tests test (p < 0.05).

Results

Enamel surface remineralization was significantly increased by Duraphat™, Duofluorid™ and 20% xylitol formulations. Significant subsurface mineral remineralization could also be seen for the experimental and commercial varnishes, except for Duraphat™, when the parameter “lesion depth” was considered.

Conclusions

20% xylitol varnish seem to be a promising alternative to increase surface and subsurface remineralization of artificial caries lesions in situ. Clinical significance: effective vehicles are desirable for caries control. Xylitol varnishes seem to be promising alternatives to increase enamel remineralization in situ, which should be confirmed by clinical studies.