Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease

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• 作者：Vasileios Tentolouris-Piperas^a ; Natalie S. Ryan^a ; David L. Thomas^a ; ^b ; Kirsi M. Kinnunen^a ; ^{k.kinnunen@ucl.ac.uk}
• 关键词：Aβ ; amyloid-beta ; AD ; Alzheimer's disease ; ADAD ; autosomal dominant Alzheimer's disease ; aMCI ; amnestic mild cognitive impairment ; ApoE ; apolipoprotein E ; CERAD ; consortium to establish a registry for Alzheimer's disease ; DIAN ; Dominantly inherited Alzheimer Network ; esMC ; early symptomatic mutation carriers ; FDG-PET ; fluorodeoxyglucose positron emission tomography ; HC ; healthy controls ; IWG ; international working group ; MC ; mutation carriers ; MCI-C ; mild cognitive impairment converters ; MCI-NC
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：23-32
• 全文大小：594 K
• 卷排序：1655

文摘

Subcortical regions may play an important role in AD development. The most consistent finding was striatal amyloid deposition in presymptomatic ADAD. Thalamo-striatal regions may also be involved in early-stage sAD. Targeted research will show if measures from these regions are useful in AD models.