Modified local diatomite as potential functional drug carrier—A model study for diclofenac sodium

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• 作者：Jelena Janićijević^a ; ^{zoran.jan@ikom.rs" class="auth_mail" title="E-mail the corresponding author} ; Danina Kraji&scaron ; nik^a ; Bojan Čalija^a ; Bojana Nedić Vasiljević^b ; Vladimir Dobričić^c ; Aleksandra Daković^d ; Milan D. Antonijević^e ; Jela Milić^a
• 关键词：Diatoms ; Porous silica ; Inorganic modification ; Adsorption ; Drug delivery ; Prolonged drug release
• 刊名：International Journal of Pharmaceutics
• 出版年：2015
• 出版时间：30 December 2015
• 年：2015
• 卷：496
• 期：2
• 页码：466-474
• 全文大小：1456 K

文摘

Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was used as a starting material. Inorganic modification of the starting material was performed through a simple, one-step procedure. Significant increase in adsorbent loading with diclofenac sodium (DS) was achieved after the modification process (∼373 mg/g) which enabled the preparation of comprimates containing therapeutic dose of the adsorbed drug. Adsorption of DS onto modified diatomite resulted in the alteration of the drug’s XRD pattern and FTIR spectrum. In vitro drug release studies in phosphate buffer pH 7.5 demonstrated prolonged DS release over 8 h from comprimates containing DS adsorbed on modified diatomite (up to 37% after 8 h) and those containing physical mixture of the same composition (up to 45% after 8 h). The results of in vivo toxicity testing on mice pointed on potential safety of both unmodified (starting) and modified diatomite. All these findings favor the application of diatomite as a potential functional drug carrier.