The SNP rs9677 of VPAC1 gene is associated with glycolipid control and heart function in female patients with type 2 diabetes: A follow-up study
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- 作者：F. Tavaglione ; T. Filardi ; M. Fallarino ; E. Mandosi ; I. Turinese ; M. Rossetti ; A. Lenzi ; S. Morano ; susanna.morano@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 2 diabetes ; Female ; Vasoactive intestinal peptide ; Vasoactive intestinal peptide receptor 1 ; Dyslipidaemia ; Cardiovascular disease
- 刊名：Nutrition, Metabolism and Cardiovascular Diseases
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：26
- 期：2
- 页码：109-113
- 全文大小：306 K
文摘
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In a previous study, the single-nucleotide polymorphism (SNP) rs9677 of VPAC1 gene was found to be associated with type 2 diabetes (T2D) in female patients.
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The CC genotype correlated with a worse glycolipid profile.
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During a follow-up for 4.6 years, a significantly increased use of statin therapy was observed in all female patients.
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No significant improvement in the low-density lipoprotein (LDL) cholesterol levels was observed in CC female patients.
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CC female patients presented a significantly higher percentage of echocardiographic abnormalities.