Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (−)-kaitocephalin

详细信息    查看全文

• 作者：Rishi G. Vaswani ; Agenor Limon ; Jorge Mauricio Reyes-Ruiz ; Ricardo Miledi ; A. Richard Chamberlin
• 关键词：Kaitocephalin ; iGluR ; Receptor antagonist ; Excitatory amino acid receptor ; AMPA receptor ; KA receptor ; Library scaffold
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2009
• 出版时间：1 January 2009
• 年：2009
• 卷：19
• 期：1
• 页码：132-135
• 全文大小：219 K

文摘

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.