Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner
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- 作者：Tomasz Ró ; ga ; Adam Orłowskia ; b ; Alicia Llorentec ; d ; Tore Skotlandc ; d ; Tuulia Sylvä ; nnee ; Dimple Kauhanene ; Kim Ekroose ; Kirsten Sandvigc ; d ; f ; Ilpo Vattulainena ; g ; h ; Ilpo.Vattulainen@tut.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：Molecular dynamics simulation ; Computer simulation ; Interdigitation ; Cholesterol ; Exosome ; Lipid membrane ; Lipidomics ; Sphingomyelin
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1858
- 期：2
- 页码：281-288
- 全文大小：1045 K
文摘
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Long-chain sphingomyelins interdigitate substantially across a lipid membrane.
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The interdigitation takes places in a cholesterol dependent fashion.
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Asymmetrical lipid distribution plays a key role in interdigitation.
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Results suggest that membrane domain coupling may take place through the process.