Catechol derivatives-coated Fe₃O₄ and γ-Fe₂O₃ nanoparticles as potential MRI contrast agents

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• 作者：H. Basti ; L. Ben Tahar ; L.S. Smiri ; F. Herbst ; M.-J. Vaulay ; F. Chau ; S. Ammar ; S. Benderbous
• 关键词：Iron oxide ; Superparamagnetism ; Catechol derivatives ; Colloid ; Magnetic resonance imaging
• 刊名：Journal of Colloid and Interface Science
• 出版年：2010
• 出版时间：15 January 2010
• 年：2010
• 卷：341
• 期：2
• 页码：248-254
• 全文大小：994 K

文摘

Superparamagnetic iron oxide nanoparticles, Fe₃O₄ and γ-Fe₂O₃, were produced by the so-called polyol process. In order to stabilize the particles in a physiological environment as potential contrast agents for Magnetic Resonance Imaging (MRI), the as-prepared particles were successfully transferred to an aqueous medium through ligand exchange chemistry of the adsorbed polyol species with the dopamine or the catechaldehyde. The ligands were able to participate in bidentate binding to the nanoparticles surface and to improve the stability of aqueous suspensions of the nanoparticles. Analysis was performed by various techniques including X-ray diffraction, transmission electron microscopy, infrared spectroscopy and thermal analysis. The results of magnetic measurements and initial in vitro magnetic resonance imaging essays are presented for the pre- and post-surface modified nanoparticles, respectively and discussed in relation with their structure and microstructure.