A novel method to induce nicotine dependence by intermittent drug delivery using osmotic minipumps
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- 作者：Julia K. Brynildsen ; Julie Najar ; Li-Ming Hsu ; D. Bruce Vaupel ; Hanbing Lu ; Thomas J. Ross ; Yihong Yang ; Elliot A. Stein ; EStein@intra.nida.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nicotine ; Nicotine dependence ; Nicotine withdrawal ; Osmotic minipump ; Mecamylamine HCl
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：79-84
- 全文大小：589 K
文摘
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Novel method to intermittently administer nicotine by osmotic minipump
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Nicotine dependence assessed as a function of dose and delivery method
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Intermittent nicotine caused more persistent dependence than continuous delivery