fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history
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- 作者：Hanbing Lu ; Svetlana Chefer ; Pradeep K. Kurup ; Karine Guillem ; D. Bruce Vaupel ; Thomas J. Ross ; Anna Moore ; Yihong Yang ; Laura L. Peoples ; Elliot A. Stein
- 关键词：Neuroadaptation ; Self-administration ; Abstinence ; Pharmacological MRI
- 刊名：NeuroImage
- 出版年：2012
- 出版时间：September, 2012
- 年：2012
- 卷：62
- 期：3
- 页码：1857-1866
- 全文大小：1178 K
文摘
Repeated cocaine exposure induces long-lasting neuroadaptations that alter subsequent responsiveness to the drug. However, systems-level investigation of these neuroplastic consequences is limited. We employed a rodent model of drug addiction to investigate neuroadaptations associated with prolonged forced abstinence after long-term cocaine self©\administration (SA). Since natural rewards also activate the mesolimbic reward system in a partially overlapping fashion as cocaine, our design also included a sucrose SA group. Rats were trained to self-administer cocaine or sucrose using a fixed-ratio one, long©\access schedule (6 h/day for 20 days). A third group of na?ve, sedentary rats served as a negative control. After 30 days of abstinence, the reactivity of the reward system was assessed with functional magnetic resonance imaging (fMRI) following an intravenous cocaine injection challenge. A strong positive fMRI response, as measured by fractional cerebral blood volume changes relative to baseline (CBV % ), was seen in the sedentary control group in such cortico-limbic regions as medial prefrontal cortex and anterior cingulate cortex. In contrast, both the cocaine and sucrose SA groups demonstrated a very similar initial negative fMRI response followed by an attenuated positive response. The magnitude of the mPFC response was significantly correlated with the total amount of reinforcer intake during the training sessions for the cocaine SA but not for the sucrose SA group. Given that the two SA groups had identical histories of operant training and handling, this region-specific group difference revealed by regression analysis may reflect the development of neuroadaptive mechanisms specifically related to the emergence of addiction-like behavior that occurs only in cocaine SA animals.