Graphene oxide functionalized with silver@silica-polyethylene glycol hybrid nanoparticles for direct electrochemical detection of quercetin

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• 作者：Murugan Veerapandian^a ; ^b ; Yeong-Tai Seo^c ; Kyusik Yun^a ; ^{ykyusik@gachon.ac.kr" class="auth_mail} ; Min-Ho Lee^d ; ^{mhlee@keti.re.kr" class="auth_mail}
• 关键词：Graphene oxide ; Chemical functionalization ; Hybrid nanoparticles ; Quercetin biosensor
• 刊名：Biosensors and Bioelectronics
• 出版年：15 August, 2014
• 年：2014
• 卷：58
• 期：Complete
• 页码：200-204
• 全文大小：1836 K

文摘

A direct electrochemical detection of quercetin based on functionalized graphene oxide modified on gold-printed circuit board chip was demonstrated in this study. Functionalized graphene oxide materials are prepared by the covalent reaction of graphene oxide with silver@silica-polyethylene glycol nanoparticles (~12.35 nm). Functionalized graphene oxide electrode shows a well-defined voltammetric response in phosphate buffered saline and catalyzes the oxidation of quercetin to quinone without the need of an enzyme. Significantly, the functionalized graphene oxide modified electrode exhibited a higher sensitivity than pristine gold-printed circuit board and graphene oxide electrodes, a wide concentration range of 7.5 to 1040 nM and detection limit of 3.57 nM. Developed biosensor platform is selective toward quercetin in the presence of an interferent molecule.