Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization
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- 作者：Minqian Shena ; 1 ; Yimin Taob ; c ; 1 ; Yifan Fenga ; Xing Liub ; c ; Fei Yuana ; yuanfei20@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Hu Zhoub ; c ; zhouhu@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNV ; corneal neovascularization ; VEGFs ; vascular endothelial growth factors ; FGFs ; fibroblast growth factors ; PDGFs ; platelet-derived growth factors ; MMPs ; matrix metalloproteinases ; sVEGFRs ; soluble VEGF receptors ; PEDF ; pigment epithelium-derived factor ; TSPs ; thrombospondins ; iTRAQ ; isobaric tags for relative and absolute quantitation ; ARVO ; Association for Research in Vision and Ophthalmology ; SCX ; strong cation exchanger ; DTT ; 1 ; 4-Dithiothreitol ; IAA ; Iodoacetamide ; CHAPS ; 3-[(3-cholamidopr
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1864
- 期：7
- 页码：787-793
- 全文大小：877 K
文摘
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Label-free quantitative proteomic approach was applied to analyze corneal tissues under alkali injury.
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2124 proteins were identified, with 290 proteins significantly changed between normal and alkali burned corneal tissues.
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Angiogenesis-related protein-protein interaction network was significantly changed during corneal neovascularization.