Study of post-compressional parameters in the friction properties of maltodextrins

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• 作者：Velasco ; M. Victoria ; Muñ ; oz-Ruiz ; Angel ; Monedero ; M. del Carmen ; Muñ ; oz-Muñ ; oz ; Nuria ; et. al.
• 关键词：Maltodextrins ; Lubrication ; Magnesium stearate ; Ejection ; Post-compressional parameters
• 刊名：International Journal of Pharmaceutics
• 出版年：1997
• 出版时间：September 12, 1997
• 年：1997
• 卷：155
• 期：1
• 页码：35-43
• 全文大小：610 K

文摘

Maltrin® M510 and M150 have been evaluated with post-compressional parameters. M150 was selected due to its sticking and friction characteristics, and another variety provided by the same supplier, M510, was also studied. Three lubricants (magnesium stearate, PRUV® and PRECIROL®) were added at different concentrations and mixing times. Tablets were compressed at three applied pressures. According to maximum ejection values, the lubricants under study behaved differently for each maltodextrin, showing that excipient characteristics determined lubricant efficiency during the ejection phase. In the residual force, the results were similar for both excipients, so it seems that the lubricant properties are critical in this phase. A novel quantitative approach to ejection curves is proposed, the work ratio, defined as the ratio between corrected ejection work with the residual force and the ejection work. Magnesium stearate mixtures showed ejection curves with low residual forces similar to type I, while PRUV® and PRECIROL® showed curves more similar to type II. The increment of concentration and mixing time lead to characteristics of type I, with low residual force and a steady ejection force during the upward movement of the tablet. For residual force and work ratio, the sequence of lubricant efficiency was similar for both excipients, with magnesium stearate the best, followed by PRUV® and PRECIROL®.