Vitamin D substrate–product relationship in idiopathic hypercalciuria

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• 作者：Maurizio Bevilacqua ; Ligia J. Dominguez ; Giorgio G ; olini ; Valeria Valdes ; Tarcisio Vago ; Velella Righini ; Massimo Barrella ; Mario Barbagallo
• 关键词：Vitamin D ; Hypercalciuria ; Kidney stones ; Metabolism ; Nutrition
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：113
• 期：1-2
• 页码：3-8
• 全文大小：205 K

文摘

Absorptive hypercalciuria (AH) is associated with elevated levels of 1,25-dihydroxyvitamin D (1,25(OH)₂D). While no increase of 1,25(OH)₂D after oral administration of 25-hydroxyvitamin D (25OHD) at high doses has been claimed in normal subjects, a substrate–product relationship has been reported in normal children, young people after UV irradiation, older persons, postmenopausal women, primary hyperparathyroidism, renal failure, osteomalacia, and sarcoidosis. No data of this relationship in AH is available. To investigate 25OHD-1,25(OH)₂D substrate–product relationship in AH, 161 AH patients (mean age 60.9 ± 11.7 years) and 110 age- and sex-matched controls (mean age 61.5 ± 12.4 years) were studied. In 57 controls and 52 AH subjects 25OHD-1,25(OH)₂D relationship in basal conditions and after 2-week oral 25OHD (25 μg/day) administration were evaluated. In basal conditions 25OHD and 1,25(OH)₂D were correlated in both, controls and AH; 25OHD treatment was followed by an increase in serum 25OHD and 1,25(OH)₂D in both groups. However, delta responses of 25OHD and 1,25(OH)₂D to 25OHD were higher in AH suggesting an enhanced activity of 1α-hydroxylase. In conclusion, the higher response of 1,25(OH)₂D after oral 25OHD in AH patients suggests a differential capacity between both groups in handling the increases in 1,25(OH)₂D.