Sensitivity of multifocal electroretinography (mfERG) in detecting siderosis

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• 作者：Shikha Gupta ; MD^* ; ^{dr.shikhagupta84@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Neha Midha ; MBBS^* ; Varun Gogia ; MD^* ; Pranita Sahay ; MBBS^* ; Veena Pandey ; BSc^&dagger ; ; Pradeep Venkatesh ; MD^*
• 刊名：Canadian Journal of Ophthalmology / Journal Canadien d'Ophtalmologie
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：50
• 期：6
• 页码：485-490
• 全文大小：2077 K

文摘

To evaluate use of multifocal electroretinography (mfERG) in diagnosing retinal toxicity from siderosis with normal ERG.

Design

Prospective case series.

Participants

Six patients with retained intraocular foreign body were recruited.

Methods

The affected eye of the patients had no clinical evidence of siderosis, had similar full-field photopic 3.0 ERG compared with the fellow eye, and had subnormal visual acuity. Group averages in each MfERG ring for implicit time and amplitude at P1 wave were compared between affected and fellow eye to look for latent siderosis.

Results

On mfERG, no statistical difference in group averaged amplitude was observed; however, a significant difference (p < 0.05) was found in group averaged latency between fellow and affected eye at most tested rings (<2 degree, 2–5 degree, and >15 degree rings). Average latency for overall retinal area mapped also showed significant difference (p = 0.010).

Conclusions

Increased mfERG latency may serve as an early predictor of retinal damage from siderosis when full-field ERG is normal.