Identification of β-Amino alcohol grafted 1,4,5 trisubstituted 1,2,3-triazoles as potent antimalarial agents
详细信息 查看全文
- 作者：Nalmala Devendera ; Sarika Gunjanb ; f ; Stuti Chhabrac ; Kartikey Singha ; Venkata Reddy Pasama ; Sanjeev K. Shuklad ; skshukla@cdri.res.in" class="auth_mail" title="E-mail the corresponding author ; Abhisheak Sharmae ; Swati Jaiswale ; Sunil Kumar Singhb ; Yogesh Kumarc ; Jawahar Lale ; Arun Kumar Trivedic ; Renu Tripathib ; f ; renu_tripathi@cdri.res.in" class="auth_mail" title="E-mail the corresponding author ; Rama Pati Tripathia ; f ; rpt.cdri@gmail.com" class="auth_mail" title="E-mail the corresponding author ; rp_tripathi@cdri.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-aminoalcohol ; Antiplasmodial ; Antimalarial ; Pharmacokinetics ; p53 protein upregulation
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：187-198
- 全文大小：1094 K
文摘
- m" id="list_ulist0010">
- •
A series of twenty four novel 1,4,5 trisubstituted 1,2,3-triazoles were synthesized.
- •
Four compounds exhibited
- •
One compound showed 89.9% parasitaemia inhibition in
- •
Compounds significantly boosted p53 protein levels.