A methodology to evaluate the thermal comfort by indoor natural ventilation in hot climates. Heat Balance Index (HBI) with heat transfer models of the human body to the surroundings. HBI for the comfort air velocity range and for the well-ventilated percentage of an indoor space. CFD simulation of natural cross-ventilation in a room used as HBI application example. CFD simulation with 3D steady RANS and SST k-ω turbulence model experimentally validated.