Ventricular premature contraction associated with mitral valve prolapse

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• 作者：Hong-TaoYuan ; MD^a ; Mei Yang ; MD^c ; Li Zhong ; MD^c ; Ying-Hsiang Lee ; MD^c ; Vaibhav R. Vaidya ; MBBS^c ; Samuel J. Asirvatham ; MD^c ; Michael J. Ackerman ; MD ; PhD^c ; Sorin V. Pislaru ; MD ; PhD^c ; Rakesh M. Suri ; MD ; DPhil^c ; Joshua P. Slusser^b ; David O. Hodge ; MS^d ; Yu-Tang Wang ; MD^a ; ^{wyt301@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Yong-Mei Cha ; MD^c ; ^{ycha@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AAD ; antiarrhythmic drug ; LVOT ; left ventricular outflow tract ; MR ; mitral regurgitation ; MVP ; mitral valve prolapse ; PISA ; proximal isovelocity surface area ; PVC ; premature ventricular contraction ; RFCA ; radiofrequency catheter ablation ; RVOT ; right ventricular outflow tract
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：1144-1149
• 全文大小：436 K

文摘

In patients with frequent premature ventricular contractions (PVCs), little is known about the profile of PVCs and the outcome of treatment in patients with mitral valve prolapse (MVP) compared to those without MVP.

Methods and results

Patients with documented PVCs between January 2001 and October 2012 were divided into 2 groups: MVP and non-MVP. The PVC characteristics, efficacy of therapy, and outcome were compared between the 2 groups. A total of 112 patients with MVP and 952 without MVP were identified. The frequency of PVCs was similar between the 2 groups (P > .05). In patients who underwent cardiac mapping, PVCs originating in papillary muscles (26.7% vs 2.3%; P < .001) and fascicle (13.3% vs 3.4%; P < .001) were more frequently seen in the MVP group than in the non-MVP group, which raises the difficulty of catheter ablation. The 2 groups had similar response to catheter ablation or medical therapy (P > .05). The survival rate was similar between the 2 groups (P = .95).

Conclusion

In patients with significant PVC burden, MVP patients had similar PVC frequency, treatment outcome, and survival rate to those without MVP.