Chagas cardiomyopathy: The potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi
详细信息 查看全文
- 作者：Fabiane M. Santosa ; b ; Ana L. Mazzetia ; Sé ; rgio Caldasd ; Karolina R. Gonç ; alvesa ; Wanderson G. Limac ; Rosá ; lia M. Torrese ; Maria Terezinha Bahiaa ; c ; mtbahia@nupeb.ufop.br" class="auth_mail" title="E-mail the corresponding author ; fabiane.santos@ufes.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trypanosoma cruzi ; Benznidazole ; Kinetoplast DNA follow-up ; Diastolic dysfunction
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：44-54
- 全文大小：2473 K
文摘
- •
The benznidazole treatment induced a transient reduction in the parasite load.
- •
A progressive increase in the parasite load could be detected a long after treatment.
- •
The treatment was unable to prevent the development of diastolic cardiac alterations.
- •
The left ventricular diastolic dysfunction can be correlated with heart damage.