Epidemiology of Pulmonary Hypertension in Left Heart Disease

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• 作者：Ashrith Guha^a ; Javier Amione-Guerra^b ; Myung H. Park^b ; ^{mhpark@houstonmethodist.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AR ; aortic regurgitation ; AS ; aortic stenosis ; AVR ; aortic valve repair ; COPD ; chronic obstructive pulmonary disease ; Cpc-PH ; combined pre and post capillary pulmonary hypertension ; DPG ; diastolic pressure gradient ; EF ; ejection fraction ; HF ; heart failure ; HFpEF ; heart failure with preserved ejection fraction ; HFrEF ; heart failure with reduced ejection fraction ; Ipc-PH ; isolated post capillary pulmonary hypertension ; LA ; left atrium ; LHD ; left heart disease ; LV ; left ventricle ; LVEDP ; left vent
• 刊名：Progress in Cardiovascular Diseases
• 出版年：2016
• 出版时间：July-August 2016
• 年：2016
• 卷：59
• 期：1
• 页码：3-10
• 全文大小：337 K

文摘

Pulmonary hypertension (PH) in the setting of left side heart disease is associated with adverse outcomes. The exact prevalence of PH in the different pathologies that affect the left ventricle, however, is difficult to access with the current literature. The lack of a standard definition of PH in older studies, the different modalities to assess pulmonary artery pressures and the varying disease severity, all account for the great variability in the reported prevalence of PH. PH can accompany heart failure (HF) with reduced (HFrEF) or preserved ejection fraction (HFpEF) as well as mitral and aortic valve disease; in any of these instances it is important to recognize whether the elevation of pulmonary pressures is driven by elevated left ventricular pressures only (isolated post-capillary PH) or if there is an accompanying remodeling component in the pulmonary arterioles (combined post-capillary and pre-capillary PH). The objective of this review is to describe the definitions, prevalence and the risk factors associated with the development of PH in the setting of HFrEF, HFpEF and valvular heart disease.