Survival and cardiovascular events after coarctation-repair in long-term follow-up (COAFU): Predictive value of clinical variables

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• 关键词：Aortic coarctation ; Cardiovascular events ; Survival
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：347-351
• 全文大小：321 K
• 卷排序：228

文摘

Long-term sequelae and events after coarctation repair are well described. However, the predictive value of variables from clinical follow-up investigation for late events and survival has rarely been investigated.MethodsAll patients who participated in the prospective cross-sectional COALA Study in 2000 with a structural clinical investigation including blood pressure measurement and symptom-limited exercise test were contacted for reevaluation of survival, current clinical status and major cardiovascular events.ResultsOf 273 eligible patients, 209 were available for follow-up. Nine patients had died at a median age of 46 years (range 30–64 years), five of them due to cardiovascular complications. Late mortality after surgical intervention was 5.7% with a median age of 41 years (range 16–64 years). Twenty-five patients had a major cardiovascular event: 12 had procedures at the aortic valve or aortic arch, 8 had procedures for restenosis, 2 had endocarditis, 2 had a cerebrovascular insult and 1 an aortic dissection. The presence of bicuspid aortic valve (p = 0.009), brachial-ankle blood pressure gradient > 20 mmHg (p < 0.001) and reduced left ventricular function (p = 0.002) correlated with major cardiovascular events.ConclusionSurgical correction of coarctation of the aorta shows fairly low mortality in the long-term follow-up. Late morbidities include recoarctation, but also the consequences of the hemodynamics produced by a congenital bicuspid aortic valve, presence of which is predictive for aortic valve procedures: however the predictive value of clinical variables is limited.