Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrous cycle
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- 作者：Ammy M. Santiagoa ; santiaa1@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Deborah J. Cleggb ; Deborah.Clegg@cshs.org" class="auth_mail" title="E-mail the corresponding author ; Vanessa H. Routha ; routhvh@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：17βE ; 17β-estradiol ; AMPK ; AMP-activated protein kinase ; ARC ; arcuate nucleus ; Cm ; membrane capacitance ; ER ; estrogen receptor ; GE ; glucose-excited ; GGT ; glucose tolerance test ; GI ; glucose-inhibited ; GSNs ; glucose-sensing neurons ; HOMA-IR ; homeostatic model assessment for insulin resistance ; IIH ; insulin-induce hypoglycemia ; IP ; intraperitoneal ; IR ; input resistance ; NGS ; non-glucose sensing ; SC ; subcutaneous ; VMH ; ventromedial hypothalamus ; VL-VMN ; ventrolateral VMN ; Vm ; membrane potential ; VM
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：167
- 期：Complete
- 页码：248-254
- 全文大小：822 K
文摘
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The response to IIH varied throughout the estrous cycle.
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Changes in hypothalamic glucose sensing coincided with those seen in the response to IIH.
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Natural fluctuations in 17βE levels may alter the response to IIH.