Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation

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• 作者：Florian Prü ; ller^a ; Reinhard B. Raggam^a ; Verena Posch^a ; Gunter Almer^a ; Martie Truschnig-Wilders^a ; Renate Horejsi^b ; Reinhard Mö ; ller^b ; Daniel Weghuber^c ; Rottraut Ille^d ; Wolfgang Schnedl^e ; Harald Mangge^a ; ^{harald.mangge@klinikum-graz.at}
• 关键词：Endogenous thrombin potential (ETP) ; Trunk obesity ; Low grade inflammation ; Thrombosis risk
• 刊名：Atherosclerosis
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：220
• 期：1
• 页码：215-218
• 全文大小：150 K

文摘

Objective

Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism.

Methods

Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58 years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance^? ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters.

Results

In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p < 0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP.

Conclusion

Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.