A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue

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• 作者：Baffa ; Raffaele ; Moreno ; Jose G. ; Monne ; Maria ; Veronese ; M. Luisa ; Gomella ; Leonard G.
• 刊名：Urology
• 出版年：1996
• 出版时间：June, 1996
• 年：1996
• 卷：47
• 期：6
• 页码：795-800
• 全文大小：574 K

文摘

Objectives. Different molecular forms of prostate-specific antigen (PSA) appear to be expressed by benign prostatic hyperplasia (BPH) compared with prostate cancer. These differences are not well understood and may arise from aberrant RNA splicing, altered protein glycosylation, or variant PSA complexing to macroglobulins. To our knowledge, a direct comparison of PSA mRNA sequences in BPH versus prostate cancer to account for these differences has not been reported. The purpose of this study was to compare the complete PSA mRNA gene sequences in benign and malignant prostate tissue to determine whether altered PSA phenotypes are a result of gene mutations and to compare the published PSA sequences.