Dose-length product of scanners correlates with DNA damage in patients undergoing contrast CT

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• 作者：Laurence Beels^a ; ^{Laurence.Beels@UGent.be} ; Klaus Bacher^a ; ¹ ; ^{Klaus.Bacher@UGent.be} ; Peter Smeets^b ; ² ; ^{Peter.Smeets@UGent.be} ; Koenraad Verstraete^b ; ³ ; ^{Koenraad.Verstraete@UGent.be} ; Anne Vral^a ; ⁴ ; ^{Anne.Vral@UGent.be} ; Hubert Thierens^a ; ⁵ ; ^{Hubert.Thierens@UGent.be}
• 关键词：Computed tomography ; Dose-length product ; DNA damage ; ¦Ã-H2AX
• 刊名：European Journal of Radiology
• 出版年：2012
• 出版时间：July, 2012
• 年：2012
• 卷：81
• 期：7
• 页码：1495-1499
• 全文大小：300 K

文摘

lass=""h4"">Objectives

Computed tomography (CT) exams contribute for a large part to the population's radiation burden. This study addresses the question if dose settings of scanners expressed by dose-length product (DLP) are correlated with directly measurable biological effects in patients.

lass=""h4"">Methods

DLP, blood dose, effective dose and DNA damage were analyzed for patients undergoing a thoracic or abdominal contrast CT scan on two CT scanners with different dose settings. The DNA damage was assessed by scoring ¦Ã-H2AX foci representing DNA double-strand breaks (DSBs) in patient's lymphocytes. Blood dose was calculated using the ImPACT software.

lass=""h4"">Results

The CT system operating at higher dose settings represented by higher DLP values, resulted in a significantly higher number of radiation-induced ¦Ã-H2AX foci in patient's lymphocytes (DLP: 2.1 times higher; ¦Ã-H2AX foci: 2.3 times higher; p < 0.05). Plotting ¦Ã-H2AX foci versus blood dose showed a systematic increase of DNA damage with dose. In vitro experiments ruled out a possible X-ray enhancement of DNA damage effect by contrast agent.

lass=""h4"">Conclusions

Present study demonstrates that optimization of DLP setting of scanners results in a reduction of X-ray effects in patients.