Role of vessel-to-prosthesis size mismatch in venous valve performance

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• 作者：Wei-Hsin Tien ; PhD^a ; Xuefeng Zhao ; PhD^b ; Henry Y. Chen ; PhD^c ; Zachary C. Berwick ; PhD^c ; Joshua F. Krieger ; BS^d ; Sean Chambers ; PhD^d ; Dana Dabiri ; PhD^e ; Ghassan S. Kassab ; PhD^b ; ^{gkassab@calmi2.org}
• 刊名：Journal of Vascular Surgery: Venous and Lymphatic Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：5
• 期：1
• 页码：105-113.e1
• 全文大小：1174 K
• 卷排序：5

文摘

Efforts to treat chronic venous insufficiency have focused on the development of prosthetic venous valves. The role of prosthetic valve-to-vessel size matching has not been determined. The purpose of this investigation was to assess the effect of size mismatching on venous valve function and to establish a mismatch limit that affects valve hemodynamic performance and venous wall stress to improve future valve designs and implants.MethodsFlow dynamics of prosthetic venous valves were studied in vitro using a pulse duplicator flow loop. Valve performance based on flow rate and pressure measurements was determined at oversizing ratios ranging from 4.2% to 25%. Valve open area ratios at different size mismatching ratios were investigated by image analysis. Finally, a wall stress analysis was used to determine the magnitude of circumferential (hoop) stress in the venous wall at various degrees of oversizing.ResultsOur findings indicate that valve regurgitate volume, closing time, and pressure difference across the valve are significantly elevated at mismatch ratios greater than ∼15%. This is supported by increases in regurgitate velocity and open area relative to valves tested at near-nominal diameters. At this degree of size mismatch, the wall stress is increased by a factor of two to three times relative to physiologic pressures.ConclusionsThese findings establish a relationship between valve size matching and valve hemodynamic performance, including vessel wall stress, which should be considered in future valve implants. The size of the prosthetic valve should be within 15% of maximum vein size to optimize venous valve hemodynamic performance and to minimize the hoop wall stress.