Synthesis, characterization, crystal structure determination and biological screening of novel N-1 and C5 alkyl substituted scaffolds of pyrimidine
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- 作者：Naziyanaz B. Pathana ; naziyaaliparvez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; parvezali_81@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Ali Parvezb ; Ammar Baderc ; Usama Shaheenc ; Taibi B. Haddad
- 关键词：Alkylpyrimidines ; Antibacterial activity ; Crystal structure ; Characterization
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：103
- 期：Complete
- 页码：594-599
- 全文大小：440 K
文摘
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The N-1 and C5 alkyl substituted derivatives of pyrimidine were synthesized.
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Crystal structure of a compound was determined.
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The new compounds were evaluated for their antibacterial activities.
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SAR of these compounds is described.