The three VGLUT isoforms have largely distinct expression patterns and synaptic properties in the adult nervous system.
Vesicular glutamate transporters (VGLUTs) are essential for pain transmission throughout the nervous system.
The distinct synaptic properties of VGLUTs affect synaptic transmission and likely also pain signaling.
They dynamic regulation of VGLUTs also affects synaptic transmission and likely pain signaling.
Understanding the dynamic nature of synaptic transmission within pain circuits may provide new strategies to treat pain.