Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism
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- 作者：Jacob Eriksen1 ; 2 ; Roger Chang1 ; 2 ; 3 ; Matt McGregor1 ; 2 ; 4 ; Katlin Silm1 ; 2 ; Toshiharu Suzuki5 ; Robert H. Edwards1 ; 2 ; 3 ; 4 ; robert.edwards@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：18 May 2016
- 年：2016
- 卷：90
- 期：4
- 页码：768-780
- 全文大小：7629 K
文摘
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VGLUTs exhibit an inwardly rectifying Cl− conductance
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Lumenal H+ and Cl− allosterically activate Cl− conductance and glutamate transport
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VGLUT3 differs from other isoforms in pH dependence and glutamate transport
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Requirement for external H+ limits glutamate efflux across the plasma membrane