Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons
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- 作者：Josiane N. Silvaa ; &dagger ; ; Elvis V. Lucenab ; &dagger ; ; Talita M. Silvab ; &dagger ; ; Rosé ; lia S. Damascenob ; Ana C. Takakuraa ; Thiago S. Moreirab ; tmoreira@icb.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDA ; biotinylated dextran amine ; FG ; FluorGold ; GAD67 ; glutamic acid decarboxylase-67 ; KF ; Kö ; lliker-Fuse ; MAP ; mean arterial pressure ; NMDA ; N-methyl-d-aspartate ; OSA ; obstructive sleep apnea ; RTN ; retrotrapezoid nucleus ; TH ; tyrosine hydroxylase ; VGLUT2 ; vesicular glutamate transporter-2 ; VRC ; ventral respiratory column
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 July 2016
- 年：2016
- 卷：328
- 期：Complete
- 页码：9-21
- 全文大小：2073 K
文摘
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Stimulation of central chemoreflex elicits an increase in genioglossal EMG activity.
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Histological evidence for glutamatergic and GABAergic inputs to the KF region from RTN chemoreceptors.
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Inhibition in KF region abolishes the GG response due to increased RTN activity.
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KF integrates and modulates breathing during chemoreceptor activation.