Drug release from layered double hydroxides and from their polylactic acid (PLA) nanocomposites

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• 作者：Marí ; a S. San Romá ; n ; Marí ; a J. Holgado ; Beatriz Salinas ; Vicente Rives ; ^{vrives@usal.es}
• 关键词：Drug release ; Polylactic acid ; Nanocomposites ; Layered double hydroxides
• 刊名：Applied Clay Science
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：71
• 期：Complete
• 页码：1-7
• 全文大小：506 K

文摘

Layered double hydroxides (LDH) with intercalated diclofenac, chloramphenicol and ketoprofen have been supported and dispersed in semicrystalline polylactic acid (PLA). The solids have been characterized by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and Fourier-Transform infrared spectroscopy (FT-IR). Drug release from the systems prepared was followed by UV-vis spectroscopy. Release is almost complete after 24 h for ketoprofen from the drug-LDH systems, but lower values were measured for the other drugs (60 and 80 % , respectively, for diclofenac and chloramphenicol); however, when supported on PLA the release was much slower and could be related to the degradation of the polymer.