MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics
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- 作者：Dhanendra Tomar1 ; 2 ; 11 ; Zhiwei Dong1 ; 2 ; 10 ; 11 ; Santhanam Shanmughapriya1 ; 2 ; 11 ; Diana A. Koch2 ; 3 ; 11 ; Toby Thomas1 ; 2 ; Nicholas E. Hoffman1 ; 2 ; Shrishiv A. Timbalia4 ; Samuel J. Goldman1 ; 2 ; Sarah L. Breves1 ; 2 ; Daniel P. Corbally1 ; 2 ; Neeharika Nemani1 ; 2 ; Joseph P. Fairweather1 ; 2 ; Allison R. Cutri1 ; 2 ; Xueqian Zhang2 ; Jianliang Song2 ; Fabiá ; n Jañ ; a1 ; 2 ; Jianhe Huang5 ; Carlos Barrero6 ; Joseph E. Rabinowitz2 ; Timothy S. Luongo2 ; Sarah M. Schumacher2 ; Michael E. Rockman1 ; 2 ; Alexander Dietrich3 ; Salim Merali6 ; Jeffrey Caplan7 ; Peter Stathopulos8 ; Rexford S. Ahima9 ; Joseph Y. Cheung2 ; Steven R. Houser5 ; Walter J. Koch2 ; Vickas Patel5 ; Vishal M. Gohil4 ; John W. Elrod2 ; Sudarsan Rajan1 ; 2 ; Muniswamy Madesh1 ; 2 ; madeshm@temple.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：24 May 2016
- 年：2016
- 卷：15
- 期：8
- 页码：1673-1685
- 全文大小：5463 K
文摘
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MCUR1 binds to MCU and EMRE and functions as a scaffold factor
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The coiled-coil domains of both MCU and MCUR1 are essential for MCU complex assembly
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Genetic deletion of MCUR1 severely impairs [Ca2+]m uptake and IMCU current
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MCUR1 deletion impairs bioenergetics and cell migration and elicits autophagy