Surgical management of pulmonary carcinoid tumors: sublobar resection versus lobectomy

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• 作者：Matthew Fox ; M.D.^a ; Victor Van Berkel ; M.D. ; Ph.D.^b ; Michael Bousamra II ; M.D.^b ; Stephen Sloan ; M.D.^c ; Robert C.G. Martin II ; M.D. ; Ph.D.^a ; ^{robert.martin@louisville.edu}
• 关键词：Carcinoid tumors ; Lung ; Survival ; Lobectomy ; Wedge
• 刊名：The American Journal of Surgery
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：205
• 期：2
• 页码：200-208
• 全文大小：868 K

文摘

<h4 class=""h4"">Backgroundh4>Surgical resection of bronchopulmonary carcinoid tumors can be curative and remains the primary treatment modality. There are limited data to delineate the optimal extent of resection for this disease.<h4 class=""h4"">Methodsh4>

A retrospective review of the 3,270 patients diagnosed with typical and atypical carcinoid tumors between 2000 and 2007 in the Surveillance Epidemiology and End Results registry was performed.<h4 class=""h4"">Resultsh4>

The mean follow-up period was 46 months (range, 1-95 mo). Overall survival (OS) and disease-specific survival at 5 years was 80 % and 90 % , respectively. The mean OS was slightly better in the lobectomy group compared with those undergoing sublobar resection (86 vs 83 mo; P = .008). After adjusting for age, this finding was no longer present (P = .513). By using multivariate analysis, sublobar resection was noninferior to lobectomy with regard to disease-specific survival and OS (P < .05).<h4 class=""h4"">Conclusionsh4>

Compared with lobectomy, sublobar resection is associated with noninferior survival in patients with typical carcinoid of the lung.