Disturbances of septohippocampal theta oscillations in the epileptic brain: Reasons and consequences

详细信息    查看全文

• 作者：Valentina Kitchigina ; Irina Popova ; Victoria Sinelnikova ; Anton Malkov ; Elena Astasheva ; Liubov Shubina ; Rubin Aliev
• 关键词：TLE ; temporal lobe epilepsy ; MSDB ; medial septal-diagonal band complex ; EEG ; electroencephalogram ; MEG ; magnetoencephalogram ; GABA ; gamma-aminobutyric acid ; Ih ; hyperpolarisation-activated non-selective cation current ; HCN ; hyperpolarisation-activated cyc
• 刊名：Experimental Neurology
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：247
• 期：Complete
• 页码：314-327
• 全文大小：1161 K

文摘

Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy, characterized by hippocampal sclerosis and memory deficits. It is well-documented that intrinsic neuronal oscillations and provided by them communications between brain structures are of importance for cognition. Epilepsy disturbs these brain rhythms and presumably therefore affects memory.

Here we review studies on cellular and systemic levels devoted to the TLE-induced disturbance of theta oscillations in the septohippocampal system. Special attention is paid to the role of damage of septal and hippocampal GABAergic cells in theta activity abnormalities. We also compare differences between native (in vivo) theta oscillations with those obtained in in vitro preparations of hippocampus and medial septum and find that in vitro they resemble epileptiform activity in some respects.