Omphalocarpoidone, a new lanostane-type furano-spiro-¦Ã-lactone from the wood of Tridesmostemon omphalocarpoides Engl. (Sapotaceae)
详细信息 查看全文
- 作者：Chi G. Fru ; Louis P. S ; jo ; Victor Kuete ; Johannes C. Liermann ; Dieter Schollmeyer ; Samuel O. Yeboah ; Renameditswe Mapitse ; Berhanu M. Abegaz ; Bonaventure T. Ngadjui ; Till Opatz
- 关键词：Structure elucidation ; Triterpene ; Lanostane ; Antibacterial
- 刊名：Phytochemistry Letters
- 出版年：2013
- 出版时间：November, 2013
- 年：2013
- 卷：6
- 期：4
- 页码：676-680
- 全文大小：639 K
文摘
Phytochemical studies of the wood and the stem bark of Tridesmostemon omphalocarpoides Engl. (Sapotaceae) led to the isolation of omphalocarpoidone (1), a new lanostane-type furano-spiro-¦Ã-lactone together with ¦Â-amyrin acetate (2), taraxerol (3), spinasterol (4), lichexanthone (5), epi-catechin (6), spinasterol 3-O-¦Â-d-glucopyranoside (7), tormentic acid (8), and 1,2,3,4-tetrahydronorharman-1-one (9). Their structures were established on the basis of extensive NMR studies, mass spectrometry, and by comparison of the data with those previously reported in the literature. The structure of the new secondary metabolite was later confirmed by X-ray crystallography. Except for spinasterol, the antimicrobial activities of these secondary metabolites were investigated on ten bacterial strains and the alkaloid 9 showed a significant activity against Escherichia coli with a MIC at 16 ¦Ìg/mL.