• 作者：Luise V. Marino ; R.D. ; Ph.D.^a ; ^{luise.marino@uhs.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Nazima Pathan ; F.R.C.P. ; Ph.D.^b ; Rosan W. Meyer ; Ph.D.^c ; Victoria J. Wright ; Ph.D.^a ; Parviz Habibi ; F.R.C.P. ; Ph.D.^a
• 关键词：KNK437 ; Glutamine ; HSP70 ; Sepsis ; Inflammatory mediators
• 刊名：Nutrition
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：32
• 期：3
• 页码：375-383
• 全文大小：1059 K

What is known:

•

Glutamine supplementation promotes heat shock protein 70 (HSP70) release in in vitro experimental models of sepsis.

•

During times of infection, HSP70 signals via cell surface ligands TLR2/4 to activate the inflammatory pathway of NF-κB, promoting the release of inflammatory mediators.

•

In an in vitro experimental model of sepsis, the HSP70 inhibitor KNK437 effectively blocks HSP70 release, diminishing the release of inflammatory mediators.

What this study adds:

•

The addition of 2 mM of glutamine to a whole blood endotoxin model promotes the release of HSP70.

•

The effect of 2 mM glutamine on HSP70 release is lost after the addition of the HSP70 inhibitor KNK437 to an in vitro model of sepsis.