Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers
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- 作者：Karolina Lecha ; Fan Liua ; Katrin Ackermanna ; b ; Victoria L. Revellc ; Oscar Laoa ; d ; Debra J. Skenec ; Manfred Kaysera ; m.kayser@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Forensic time estimation ; Blood deposition time ; Circadian hormones ; Rhythmic gene expression ; mRNA
- 刊名：Forensic Science International: Genetics
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：21
- 期：Complete
- 页码：119-125
- 全文大小：267 K
文摘
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Knowing the time a human trace was left at a crime scene is crucial for solving the case.
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We recently showed that timing trace deposition with circadian hormones is feasible.
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Here we access the suitability of 21 mRNA markers for blood deposition timing.
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We present 11 rhythmic mRNAs from analysing blood collected every 2 h for 36 h.
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Three mRNAs, melatonin, cortisol allow estimating 3 time categories with AUC 0.88-0.95.