Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adults

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• 作者：Maria Claudia Peixoto Cenci ; D¨¦bora Vieira Soares ; Luciana Diniz Carneiro Spina ; Rosane Resende de Lima Oliveira Brasil ; Priscila Marise Lobo ; Eduardo Michmacher ; Mario Vaisman ; Cesar Luiz Boguszewski ; Fl¨¢via L¨²cia Concei??o
• 关键词：GH deficiency in adults ; Hypopituitarism ; GH substitution
• 刊名：Growth Hormone IGF Research
• 出版年：2012
• 出版时间：June-August, 2012
• 年：2012
• 卷：22
• 期：3-4
• 页码：116-121
• 全文大小：260 K

文摘

Objective

To compare the effects of two regimens of GH therapy with different target IGF-1 levels on anthropometric parameters, glucose metabolism, lipid profile and cardiac function in adults with GH deficiency (GHD).

Patients and methods

Retrospective analysis of 14 GHD adults from Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil, who were treated with a GH regimen aimed at maintaining serum IGF-1 levels between the median and upper reference limit (high dose group ¡ª HDGH) and 18 GHD adults from Federal University Hospital, Curitiba, Brazil, who received a fixed GH dose of 0.2 mg/day in the first year of treatment, followed by titration to maintain serum IGF-1 levels between the median and lower reference limit (low dose group ¡ª LDGH). All patients were followed for 2 years with analysis of anthropometric parameters, serum levels of IGF-1, glucose, insulin, HOMA-IR, lipid profile, and transthoracic echocardiography.

Results

Changes on weight, BMI and waist circumference were similar between the two groups. Insulin levels increased and HOMA-IR worsened in the LDGH group at 1 year and improved thereafter. Total cholesterol and triglycerides did not change with therapy. LDL cholesterol reduced in both groups, while HDL-cholesterol significantly increased only in the HDGH group (p = 0.007 vs LDGH). No significant variations on echocardiographic parameters were observed.

Conclusion

The HDGH and LDGH regimens resulted in similar changes on anthropometric, echocardiographic, glucose and lipid parameters in GHD adults, except for increase in HDL cholesterol that was only observed in the HDGH regimen.