Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice
详细信息 查看全文
- 作者：Juliana Magdalona ; 1 ; Patricia Chimina ; 1 ; Thiago Belchiora ; Rodrigo X. Nevesb ; Marcel A. Vieira-Larac ; Maynara L. Andradea ; Talita S. Fariasa ; Andressa Bolsoni-Lopesa ; Vivian A. Paschoala ; Alex S. Yamashitaa ; Alicia J. Kowaltowskic ; William T. Festucciaa ; william.festuccia@usp.br" class="auth_mail" title="E-mail the corresponding author ; william.festuccia@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：4E-BP ; eukaryotic initiation factor 4E-binding protein ; ATscKO ; Tsc1Lox/Lox adiponectin-cre+/&minus ; mice ; ATscWT ; Tsc1Lox/Lox adiponectin-cre&minus ; /&minus ; mice ; C/EBP ; CCAAT/enhancer-binding protein ; CYC1 ; cytochrome c-1 ; DEPTOR ; DEP domain-containing mTOR-interacting protein ; ERR ; estrogen-related receptor ; GTT ; glucose tolerance test ; HFD ; high-fat diet ; iBAT ; interscapular brown adipose tissue ; IRS ; insulin receptor substrate ; iWAT ; inguinal white adipose tissue ; LPL ; lipoprotein lipase
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1861
- 期：5
- 页码：430-438
- 全文大小：2570 K
文摘
- •
Adipocyte Tsc1 deletion reduces visceral adiposity in male mice.
- •
Adipocyte Tsc1 deletion enhances fat mitochondrial oxidative activity and fatty acid oxidation.
- •
Adipocyte Tsc1 deletion promotes browning in mice visceral fat.