Integrative functional genomic analysis unveils the differing dysregulated metabolic processes across hepatocellular carcinoma stages
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- 作者：Vignesh Ramesh ; Kumaresan Ganesan
- 关键词：AFP ; alpha fetoprotein ; ALP ; alkaline phosphatase ; BCLC ; Barcelona-Clinic Liver Cancer ; CLIP ; Cancer of the Liver Italian Program ; DEN ; diethylnitrosamine ; GEO ; Gene Expression Omnibus ; HCC ; hepatocellular carcinoma ; HCV ; hepatitis C virus ; TCA ; tricarboxylic acid ; TCGA ; The Cancer Genome Atlas ; TNM ; tumor-node-metastasis ; WGCNA ; Weighted Gene Co-expression Network Analysis
- 刊名：Gene
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：588
- 期：1
- 页码：19-29
- 全文大小：2317 K
文摘
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- <p id="p0005">Three metabolic process related gene-sets show deregulation in HCC transcriptome.p>
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- <p id="p0010">Fatty acid, inflammatory & nucleic acid metabolism are the three dysregulations.p>
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- <p id="p0015">These three metabolic gene-sets also represent the three HCC sub-types.p>
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- <p id="p0020">Deregulations in metabolic gene-sets are also found in HCC cells.p>