Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice
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- 作者：Vigneshwaran Pitchaimania ; Somasundaram Arumugama ; Rajarajan Amirthalingam Thandavarayanb ; Vengadeshprabhu Karuppagoundera ; Mst. Rejina Afrina ; Remya Sreedhara ; Meilei Harimaa ; Hiroshi Suzukia ; Shizuka Miyashitaa ; Takashi Nakamuraa ; Kenji Suzukic ; Masahiko Nakamurad ; Kazuyuki Uenoe ; Kenichi Watanabea ; watanabe@nupals.ac.jp" class="auth_mail" title="E-mail the corresponding author ; somasundaram143@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATP ; adenosine triphosphate ; BGL ; blood glucose level ; F ; fasting ; i.p ; intraperitoneally ; H ; hour ; IIHS ; insulin induced hypoglycemic seizures ; INS ; insulin ; NMDA ; N methyl D aspartate ; U ; unit ; USP ; United States Pharmacopeia
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：47-51
- 全文大小：464 K
文摘
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Fasting duration 6 h and 24 h modulate insulin-induced hypoglycemic seizure onset.
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The quick seizure onset in 6 h fasted mice was possibly due to lower ketone levels.
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The late seizure onset in 24 h fasted mice was possibly due to higher ketone levels.