The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration

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• 作者：Vijay Bhaskar Reddy Konala¹ ; ² ; Murali Krishna Mamidi³ ; Ramesh Bhonde³ ; Anjan Kumar Das⁴ ; Radhika Pochampally⁵ ; Rajarshi Pal³ ; ^{rajarshi.pal@manipal.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cell therapy ; exosomes ; mesenchymal stromal cells ; regeneration ; secretome
• 刊名：Cytotherapy
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：18
• 期：1
• 页码：13-24
• 全文大小：2116 K

文摘

The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and anti-apoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.