An attenuated calcium signaling and pre-emptive activation of UPR pathway together contribute to ER and calcium stress resilience of Lepidopteran insect cells

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• 作者：Ayushi Guleria ; Vijaypal Singh ; Sudhir Chandna ; ^{sudhirchandna@yahoo.com}
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1861
• 期：3
• 页码：504-521
• 全文大小：4377 K
• 卷排序：1861

文摘

Lack of cytosolic calcium release by radiation recently shown in Sf9 insect cells. Sf9 cells resist cytosolic/mitochondrial calcium accumulation by ER stress agents. Calcium mediated pro-apoptotic CaMKII-JNK pathway strongly attenuated in Sf9 cells. High basal level of UPR markers indicates preemptive and protective UPR signaling. Synergy of calcium regulation and UPR enhances ER stress resistance of Sf9 cells.