Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats
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- 作者：Vengadeshprabhu Karuppagoundera ; Somasundaram Arumugama ; Rajarajan A. Thandavarayanb ; Remya Sreedhara ; Vijayasree V. Giridharanc ; Rejina Afrina ; Meilei Harimaa ; Shizuki Miyashitaa ; Masanori Harad ; Kenji Suzukie ; Masahiko Nakamuraf ; Kazuyuki Uenog ; Kenichi Watanabea ; watanabe@nupals.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Curcumin ; Macrophage ; Cluster of differentiation 163 ; Nuclear factor kappa B ; Cytokine
- 刊名：Cytokine
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：1-9
- 全文大小：3294 K
文摘
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Curcumin ameliorates daunorubicin induced nephrotoxicity in rats.
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Curcumin effectively reduced M1 macrophage phenotype.
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Treatment with curcumin suppressed inflammatory protein expression.
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Curcumin also increased M2 macrophage phenotype.
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Curcumin shifting M1 to M2 macrophage polarization in DNR treated kidney.