Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions

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• 作者：Vikas S. Patil ; Shyam S. Pal ; Ramdas S. Pathare ; L.K.K. Reddy ; Arunendra Pathak
• 关键词：Azaindole ; Aminocarbonylation ; Oxindoles
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：18 November 2015
• 年：2015
• 卷：56
• 期：46
• 页码：6370-6372
• 全文大小：2537 K

文摘

Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives.