Designing galacturonic acid /arabinogalactan crosslinked poly(vinyl pyrrolidone)- co-poly(2-acrylamido-2-methylpropane sulfonic acid) polymers: Synthesis, characterization and drug delivery application
详细信息 查看全文
- 作者：Baljit Singh ; baljitsinghhpu@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Vikrant Sharma
- 关键词：PVP ; Mucoadhesive hydrogels ; Drug delivery ; GIT
- 刊名：Polymer
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：50-61
- 全文大小：1547 K
文摘
- •
Mesh size of hydrogels decreased with increase in [NN-MBA].
- •
MW of the polymer chain between two neighboring cross links decreased with increase in [NN-MBA].
- •
The release of drug occurred through a non-Fickian diffusion mechanism.
- •
Drug release best fitted in Higuchi square root model.
- •
Polymers have been observed as mucoadhesive and non-thrombogenic.