Influence of polymer network parameters of tragacanth gum-based pH responsive hydrogels on drug delivery

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• 作者：Baljit Singh ; Vikrant Sharma
• 关键词：Network parameters ; Drug delivery ; Amoxicillin ; pH responsive hydrogels
• 刊名：Carbohydrate Polymers
• 出版年：30 January, 2014
• 年：2014
• 卷：101
• 期：Complete
• 页码：928-940
• 全文大小：1618 K

文摘

The present article deals with design of tragacanth gum-based pH responsive hydrogel drug delivery systems. The characterization of hydrogels has been carried out by SEMs, EDAX, FTIR, ¹³C NMR, XRD, TGA/DTA/DTG and swelling studies. The correlation between reaction conditions and structural parameters of polymer networks such as polymer volume fraction in the swollen state (蠒), Flory-Huggins interaction parameter (蠂), molecular weight of the polymer chain between two neighboring cross links (), crosslink density (蟻) and mesh size (尉) has been determined. The different kinetic models such as zero order, first order, Higuchi square root law, Korsmeyer-Peppas model and Hixson-Crowell cube root model were applied and it has been observed that release profile of amoxicillin best followed the first order model for the release of drug from the polymer matrix. The swelling of the hydrogels and release of drug from the drug loaded hydrogels occurred through non-Fickian diffusion mechanism in pH 7.4 solution.