Objective optical assessment of tear-film quality dynamics in normal and mildly symptomatic dry eyes

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• 作者：Antonio Benito PhD^a ; Guillermo M. Pé ; rez PhD^a ; Sandra Mirabet MD^a ; Meritxell Vilaseca PhD^a ; Jaume Pujol PhD^a ; José ; M. Marí ; n MD ; PhD^a ; Pablo Artal PhD ; ^a ; ^{pablo@um.es"" rel=""nofollow}
• 刊名：Journal of Cataract and Refractive Surgery
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：37
• 期：8
• 页码：1481-1487
• 全文大小：450 K

文摘

Purpose

To evaluate and compare the tear-film dynamics in normal eyes and in eyes with mild dry-eye symptoms using a new noninvasive optical method based on a double-pass instrument.

Setting

Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

Design

Evaluation of diagnostic test or technology.

Methods

Dynamic recording of double-pass retinal images during unforced tear-film breakup was performed in eyes with mild dry-eye symptoms (study group) and in an asymptomatic control group. Series of consecutive retinal images were recorded every 0.5 seconds while the patient avoided blinking. Measurements were performed under low-light conditions to naturally increase pupil diameter and maximize the method's sensitivity. Additional clinical tests were performed for comparison and included tear breakup time (TBUT), Schirmer I tests, and a normalized questionnaire (McMonnies). From the retinal images, a quality metric, the intensity distribution index, was calculated. An objective TBUT value was estimated in each eye when the intensity distribution index surpassed a defined threshold value compared with the initial baseline.

Results

The study group comprised 20 eyes and the control group, 18 eyes. Symptomatic dry eyes had a typical exponential increase in the intensity distribution index with time. The objective TBUT values in the study group were comparable to the clinical TBUT estimates.

Conclusions

The new objective optical method to evaluate the quality and stability of the tear film was sensitive in detecting mild symptoms of dry eye and differentiating from normal cases. The procedure may allow early detection and follow-up of patients' tear film–related complaints.

Financial Disclosure

No author has a financial or proprietary interest in any material or method mentioned.