JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
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- 作者：Michael Van Meter1 ; Matthew Simon1 ; Gregory Tombline1 ; Alfred May2 ; Timothy D. Morello1 ; Basil P. Hubbard3 ; Katie Bredbenner1 ; Rosa Park1 ; David A. Sinclair3 ; Vilhelm A. Bohr2 ; Vera Gorbunova1 ; 4 ; vera.gorbunova@rochester.edu" class="auth_mail" title="E-mail the corresponding author ; Andrei Seluanov1 ; andrei.seluanov@rochester.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2641-2650
- 全文大小：2451 K
文摘
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JNK phosphorylates SIRT6 at residue S10 in response to oxidative stress
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SIRT6 S10 phosphorylation is required for the stimulation of DNA break repair
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SIRT6 S10 phosphorylation stimulates SIRT6 mono-ADP ribosylation activity on PARP1