TIS21^/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade

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• 作者：In Kyoung Lim^a ; ^b ; ^{iklim@ajou.ac.kr} ; Jung-A Choi^a ; Eun Young Kim^b ; Bit Na Kim^b ; Soohyun Jang^c ; Min Sook Ryu^b ; Sang-Hee Shim^c
• 关键词：NADPH oxidase 4 (Nox4) ; Reactive oxygen species (ROS) ; Diaphanous-related formin (DRF) ; Abl-interactor 2 (ABI2) ; Actin stress fiber ; Vimentin
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：179-190
• 全文大小：1839 K
• 卷排序：30

文摘

Doxorubicin induces senescence by actin stress fiber formation via Nox4-ROS pathway. Doxorubicin-induced linear actin-vimentin networks are inhibited by TIS21/BTG2 gene. The linear actin nucleation is transmitted via Nox4-ROS-ABI2-DRF signal cascade. TIS21/BTG2 downregulates the signal pathways regulating actin-vimentin networks. TIS21/BTG2 attenuates doxorubicin-induced cancer cell senescence.