Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

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• 作者：Gautier M.A. Ndong Ntoutoume^a ; Robert Granet^a ; Jean Pierre Mbakidi^a ; Fré ; dé ; rique Bré ; gier^a ; David Y. Lé ; ger^a ; Chloë ; Fidanzi-Dugas^a ; Vincent Lequart^b ; Nicolas Joly^b ; Bertrand Liagre^a ; Vincent Chaleix^a ; Vincent Sol^a ; ^{vincent.sol@unilim.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cellulose nanocrystals ; Nanoparticles ; Curcumin ; Drug delivery ; Cancer cells
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：26
• 期：3
• 页码：941-945
• 全文大小：1135 K

文摘

The synthesis of curcumin–cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin–CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC₅₀s lower than that of curcumin alone.